Monday, June 30, 2008
Our Genome Changes Over Lifetime
"We're beginning to see that epigenetics stands at the center of modern medicine because epigenetic changes, unlike DNA sequence which is the same in every cell, can occur as a result of dietary and other environmental exposure," says Andrew P. Feinberg, M.D., M.P.H, a professor of molecular biology and genetics and director of the Epigenetics Center at the Johns Hopkins School of Medicine. "Epigenetics might very well play a role in diseases like diabetes, autism and cancer."
More HERE.
Baby to be born free of breast cancer after embryo screening
A woman has conceived Britain’s first baby guaranteed to be free from hereditary breast cancer.
Doctors screened out from the woman’s embryos an inherited gene that would have left the baby with a greater than 50% chance of developing the cancer.
The woman decided to have her embryos screened because her husband had tested positive for the gene and his sister, mother, grandmother and cousin have all had the cancer.
The couple produced 11 embryos, of which five were found to be free from the gene. Two of these were implanted in the woman’s womb and she is now 14 weeks pregnant.
More HERE.
Building Giant 'Nanoassemblies' That Sense Their Environment
The study, scheduled for the July 9 issue of ACS's Nano Letters, a monthly journal, terms those structures "giant" because they are about the size of a grain of rice — millions of times larger than anything in the submicroscopic realm of the nanoworld.
In the new study, Pulickel M. Ajayan and colleagues point out that such structures are a step toward the development of futuristic nanomachines with practical applications in delivering medicines to patients, labs-on-a-chip, and other products. Until now, scientists have had difficulty in using nanomaterials to build more complex, multifunctional objects needed for those applications.
More HERE.
Saturday, June 28, 2008
Definition: Proteome
It was coined by Marc Wilkins first in 1994 in the symposium: "2D Electrophoresis: from protein maps to genomes" in Siena, Italy, and was subsequently published in 1995 (1), which was part of his PhD thesis. Wilkins used it to describe the entire complement of proteins expressed by a genome, cell, tissue or organism.
More HERE.
Calculation predicts death row executions
Which inmates on death row will eventually be executed? Many never make the final journey from prison cell to execution chamber - but nobody really understands who will be spared. Until now. A new computer system can predict which death row prisoners will live and which will be killed - with chilling accuracy. And its dispassionate analysis has confirmed suspicions that the people most likely to be executed are those who have had the least schooling, rather than those who have committed the most heinous crimes.
So how were those 53 chosen? "We couldn't see any clear patterns in the data," says computer scientist Stamos Karamouzis, who has been investigating this question with criminologist Dee Wood Harper at Loyola University in New Orleans, Louisiana.
How a 730-Ton Ball Kept the Second Tallest Building From Falling During the Chinese Earthquake
The recent Sichuan Earthquake in China was so intense, tremors were felt all the way over in the tallest completed building in the world—the Taipei 101 building in Taiwan—a whole eight minutes after the quake originated. What's interesting about the 101 is that it has a gigantic suspended tuned mass damper, or hanging ball, which takes up four stories and works like this to prevent the building from falling over and tragically crushing office workers. This 730 ton sphere looks intimidating when still, but wait until you see it in motion during the earthquake.
More HERE.
Martian Soil Could Grow Asparagus
Full story HERE.
Thursday, June 26, 2008
Monday, June 23, 2008
Math Could Help Cure Leukemia
University of Maryland associate professor of mathematics Doron Levy, Stanford Medical School physician and associate professor of medicine (hematology) Peter P. Lee, and Dr. Peter S. Kim, École Supérieure d'Électricité (Gif-sur-Yvette, France) describe their success in creating a mathematical model which predicts that anti-leukemia immune response in CML patients using the drug imatinib can be stimulated in a way that might provide a cure for the disease.
"By combining novel biological data and mathematical modeling, we found rules for designing adaptive treatments for each specific patient," said Levy, of the University of Maryland Center for Scientific Computation and Mathematical Modeling. "Give me a thousand patients and, with this mathematical model, I can give you a thousand different customized treatment plans."
Full story HERE.
Microscopic 'Clutch' Puts Flagellum In Neutral
A tiny but powerful engine that propels the bacterium Bacillus subtilis through liquids is disengaged from the corkscrew-like flagellum by a protein clutch, Indiana University Bloomington and Harvard University scientists have learned. Their report appears in Science on June 20.
Scientists have long known what drives the flagellum to spin, but what causes the flagellum to stop spinning -- temporarily or permanently -- was unknown.
"We think it's pretty cool that evolving bacteria and human engineers arrived at a similar solution to the same problem," said IU Bloomington biologist Daniel Kearns, who led the project. "How do you temporarily stop a motor once it gets going?"
Full story HERE.
Friday, June 20, 2008
Interview: Why our brains are so clumsy
In his new book, Kluge: The haphazard construction of the human mind, Gary Marcus aims to take the human species down a peg or two. We might like to think of ourselves as sleek and perfectly-adapted products of evolution, but Marcus instead describes the brain as a clumsy collection of spare parts. If evolution is so powerful, he asks, how did we end up so flawed? Jo Marchant caught up with him.
What exactly is a kluge?
A kluge is a clumsy or inelegant solution to a problem that gets the job done, but not necessarily in the best way possible.
Why do you think that the mind is a kluge?
There are two answers to that. The first is a general argument about evolution: that if you look at evolution it makes a lot of kluges. Evolution tends not to optimise things; it simply tinkers with what's already there. So it tends to make things better but there's no guarantee that it will make the best.
The second is an empirical argument. I look to see whether there is anything clumsy about the human mind, and I find lots of examples.
Full story HERE.
Bugs that eat waste and excrete petrol
He means bugs. To be more precise: the genetic alteration of bugs – very, very small ones – so that when they feed on agricultural waste such as woodchips or wheat straw, they do something extraordinary. They excrete crude oil.
Unbelievably, this is not science fiction. Mr Pal holds up a small beaker of bug excretion that could, theoretically, be poured into the tank of the giant Lexus SUV next to us. Not that Mr Pal is willing to risk it just yet. He gives it a month before the first vehicle is filled up on what he calls “renewable petroleum”. After that, he grins, “it’s a brave new world”.
Full story HERE.
New Cancer Treatment Targets Both Tumor Cells and Blood Vessels
“Tumors are entities that want to live,” said Salman Hyder, professor of biomedical sciences in the College of Veterinary Medicine and the Dalton Cardiovascular Research Center. “They adapt under conditions that would cause anything else to die. In order to effectively treat tumors, treatments must attack the breast tumor cells and the blood vessels that supply nutrients to the tumor. Treatment strategies in our study that targeted both areas resulted in improved and more potent responses.”
Full story HERE.
Thursday, June 19, 2008
Bacteria anticipate coming changes in their environment
The research team, which included biologists and engineers, used lab experiments to demonstrate this phenomenon in common bacteria. They also turned to computer simulations to explain how a microbe species' internal network of genes and proteins could evolve over time to produce such complex behavior.
"The two lines of investigation came together nicely to show how simple biochemical networks can perform sophisticated computational tasks," says Tavazoie.
Full story HERE.
Ten Times the Turbine
“The wind-turbine design out there right now is a thousand years old,” Selsam points out, as he lets one of his carved wooden blades speed to a blur in the makeshift wind tunnel he’s made of the alley behind his Fullerton, California, apartment. He brainstormed his multi-rotor approach in the early ’80s, in a fluid-dynamics class at the University of California at Irvine. “The textbook said, this single-rotor turbine design is the most power you can get. I knew then it wasn’t right. More rotors equals more power.”
Full story HERE.
Cheap Lamps Made with Aluminum Foil
Researchers at the University of Illinois at Urbana-Champaign made the low-cost lamps by treating aluminum foil bought at the grocery store with an acidic bath. The new light source, which is lighter, brighter, and more efficient than incandescent light, is described in the June issue of the Journal of Physics D: Applied Physics.
"We wanted to make this technology as inexpensive as we possibly could," said physicist Gary Eden. "Expensive technology can be interesting, but the opportunity for using it is limited."
The alternative light source developed by Eden and colleagues is built of foil bathed in acid so that its surface is full of tiny holes. The acid also converts the foil into sapphire, a type of aluminum oxide, which creates a robust structure that allows volts to travel across the thin layer of aluminum without breaking it down. The tens of thousands of cavities are filled with gas and wired together, and the whole device is sealed between two pieces of glass or something similar.
Full story HERE.
Monday, June 16, 2008
MIT students build advanced all-electric Porsche
"In the laboratory we work on materials to make batteries safer, last longer and have higher energy," she said. "But we are also interested in gaining a good perspective on the system. What's involved in building an electric vehicle, and what's required of the batteries?"
The student project took off last year when Valence Technology Inc. donated 18 lithium phosphate rechargeable batteries valued at $2,030 each, plus a battery-management system. The team began by removing the original engine, exhaust lines and fuel tank and installing an electric motor and motor controller, the batteries and battery-management system, a battery charger and various smaller components. Each of the batteries is equipped with a built-in computer that monitors its conditions--ideal for the data-gathering task.
Full story HERE.
Microchip sets low-power record
ANN ARBOR, Mich.—A low-power microchip developed at the University of Michigan uses 30,000 times less power in sleep mode and 10 times less in active mode than comparable chips now on the market.
The Phoenix Processor, which sets a low-power record, is intended for use in cutting-edge sensor-based devices such as medical implants, environment monitors or surveillance equipment.
The chip consumes just 30 picowatts during sleep mode. A picowatt is one-trillionth of a watt. Theoretically, the energy stored in a watch battery would be enough to run the Phoenix for 263 years.
Full story HERE.
Earliest genetic material may have come from the stars
The finding suggests that parts of the raw materials to make the first molecules of DNA and RNA may have come from the stars.
The scientists, from Europe and the USA, say that their research, published in the journal Earth and Planetary Science Letters, provides evidence that life's raw materials came from sources beyond the Earth.
The materials they have found include the molecules uracil and xanthine, which are precursors to the molecules that make up DNA and RNA, and are known as nucleobases.
Full story HERE.
Saturday, June 14, 2008
Nano-tech Process Produces Plastics 10 Times More Stretchable
Zhao-Xia Guo and colleagues point out that the original plastic, called polyoxymethylene (POM), is an engineering staple known for its metal-like hardness, light weight, and resistance to chemicals. However, the material is relatively brittle, limiting its applications. Although many different types of plastics have been electrospun into fibers with extended uses and properties, researchers have been unable to spin POM into fibers until now, the researchers say.
Full story HERE.
Definition: Orrery
According to Cicero, the Greek philosopher Posidonius constructed an orrery, possibly similar or identical to the Antikythera mechanism, which exhibited the diurnal motions of the sun, moon, and the five known planets. Cicero's account was written in the first century BC.
More HERE.
Fossilized Burrows In Antarctica
The fossils were created when fine sand from an overflowing river poured into the animals' burrows and hardened into casts of the open spaces. The largest preserved piece is about 14 inches long, 6 inches wide and 3 inches deep. No animal remains were found inside the burrow casts, but the hardened sediment in each burrow preserved a track made as the animals entered and exited.
Full story HERE.
Friday, June 13, 2008
Nanoscope peers beyond the limits of light
The power of light microscopes to resolve fine details has just doubled. A new technique can distinguish tiny structures inside cells, in colour and 3D, even if they are only 100 nanometres apart.
"We have opened a door to a whole new world of structures that you could not see and study before," says Heinrich Leonhardt of the Center for Integrated Protein Science at the Ludwig Maximilians University in Munich, Germany.
Full story HERE.
Human Travel Patterns Surprisingly Predictable
“We were surprised by some of the aspects of the study,” says lead author Marta González. “There is a lot of similarity between the behavior of people.”
The study analyzed human motion by monitoring cellphone records and tracking each phone’s signal as it moved from one phone tower to the next. They used the data to come up with a probability equation for describing human movement. The results could have implications for urban planning, traffic monitoring, and the spread of disease, all of which rely on human travel.
Full story HERE.
Wednesday, June 11, 2008
Bionic hand wins top tech prize
The world's most advanced, commercially available, bionic hand has clinched the UK's top engineering prize. The i-LIMB, a prosthetic device with five individually powered digits, beat three other finalists to win this year's MacRobert award. The technology has been fitted to more than 200 people, including US soldiers who lost limbs during the war in Iraq.
The device started life in Scotland in 1963 as part of a project to help children affected by Thalidomide. The complex device finally went on sale in July 2007. It is produced by a company called Touch Bionics based in Mid Calder, Livingston.
Full story with VIDEO HERE.
Dead Zones Grow in the Gulf of Mexico
Scientists have monitored the growth of these so-called dead zones since the late 1970s. They have tried to promote policies to reduce their size, without much success. Last summer, the dead zone along the Gulf of Mexico coast spanned nearly 8,000 square miles— its third-largest occurrence on record and roughly the size of Massachusetts.
Full story HERE.
Monday, June 9, 2008
School Of Robofish Communicate With Each Other
Over the past five years Kristi Morgansen, a University of Washington assistant professor of aeronautics and astronautics, has built three Robofish that communicate with one another underwater. Recently at the International Federation of Automatic Control's Workshop on Navigation, Guidance and Control of Underwater Vehicles she presented results showing that the robots had successfully completed their first major test. The robots were programmed to either all swim in one direction or all swim in different directions, basic tasks that can provide the building blocks for coordinated group movement.
This success in indoor test tanks, she said, will eventually provide the basis for ocean-going systems to better explore remote ocean environments.
Full story HERE.
Sun goes longer than normal without producing sunspots
That's good news for people who scramble when space weather interferes with their technology, but it became a point of discussion for the scientists who attended an international solar conference at Montana State University. Approximately 100 scientists from Europe, Asia, Latin America, Africa and North America gathered June 1-6 to talk about "Solar Variability, Earth's Climate and the Space Environment."
The scientists said periods of inactivity are normal for the sun, but this period has gone on longer than usual.
Full story HERE.
Livermore researchers use carbon nanotubes for molecular transport
In biological systems, the membranes often contain a slippery inner surface with selective filter regions made up of specialized protein channels of sub-nanometer size. These pores regulate cellular traffic, allowing some of the smallest molecules in the world to traverse the membrane extremely quickly, while at the same time rejecting other small molecules and ions.
Researchers at Lawrence Livermore National Laboratory are mimicking that process with manmade carbon nanotube membranes, which have pores that are 100,000 times smaller than a human hair, and were able to determine the rejection mechanism within the pores.
Full story HERE.
Sunday, June 8, 2008
Self-experimentation as a source of new ideas
"Does standing up a lot during the day reduce susceptibility to colds? Go ahead and doubt it; I did. But Roberts has data to back it up, and while it would be foolish to believe that standing up a lot during the day would eliminate colds across an entire population -- foolish, that is, without experiments to prove it -- Roberts' own practice of standing up a lot has a lot more empirical back-up than many of the more "sensible" things we naively believe.
"Here's anther one: for a long time Roberts had a problem with his sleep. He woke too early, could not go back to sleep, and then was tired in the morning. He tried different ways to cure this problem until, through a combination of coincidence, experiment and analysis of the data, he discovered an expected correlation: his problem disappeared when he skipped breakfast. He cured his early awakening by not eating until 11 a.m.
"The idea that skipping breakfast may reduce early awakening was, wrote Roberts, "a new idea in sleep research." Strangely, Roberts was not hungry in the wee hours when he was troubled by early awakening, which lead him to suspect that it was not discomfort that roused him, but rather some glitch in his sleep cycle caused by anticipation of food."
More HERE.
Stupid flies live longer
"In other terms, the more the fly becomes intelligent, the shorter its lifespan," the scientists said.
This is most probably because the increase in neural activity weakens the fly's life-support systems, they speculated.
Full story HERE.Micro-fossils discovered in harshest environments on Earth
Kathleen Benison, a geologist at Central Michigan University, Mount Pleasant, led a team that studied the sediments formed by acidic and very salty lakes in modern day Western Australia, and those deposited around 250 million years ago in North Dakota. It is very difficult to survive in such a tough environments and few signs of life have ever been found in these sorts of lakes.
Saturday, June 7, 2008
Giant telescopes could be built from Moon dust
Using the mixture, they built a 30-centimetre disc. Then they added more liquid epoxy to its surface and spun it, coating it with aluminium in a vacuum. They believe the process could be scaled up to produce 20- to 50-metre-wide telescopes on the Moon. That would be useful, says Chen, since the limited fuel and cargo capacities of rockets make it unfeasible to launch large mirrors or telescopes to the Moon. "By this technique, we are no longer restricted by how much a rocket can carry," Chen said.
Full story HERE.
NASA appointees suppressed climate data
WASHINGTON — Political appointees at NASA headquarters deliberately downplayed scientific evidence documenting global warming for political reasons for more than a year, the agency's watchdog reported Monday. Kevin Winters, NASA's assistant inspector general for investigations, outlined his findings in a 93-page report evaluating allegations that the agency's public affairs specialists suppressed climate change science and denied National Public Radio access to Dr. James Hansen, a NASA scientist.
Winters said his investigation found that NASA headquarters' public affairs specialists "managed the topic of climate change in a manner that reduced, marginalized, or mischaracterized climate change science made available to the general public" from fall 2004 through early 2006. Investigators, who interviewed 59 witnesses and reviewed 10,000 pages of documents, attributed the actions to "inappropriate political posturing or advantage."
Full story HERE.Definition: Aerobraking
Full story HERE.
More HERE.
Interactive illustration HERE.
Thursday, June 5, 2008
New superconductors
"It appears to us that the new iron-based superconductors disclose a new physics, contain new mysteries and may start us along an uncharted pathway to room temperature superconductivity," said Chien, who teamed up on the research with Tingyong Chen and Zlatko Tesanovic, both of Johns Hopkins, and X.H. Chen and R.H. Liu of the Hefei National Laboratory for Physical Science at Microscale and Department of Physics, University of Science and Technology of China in Anhui, China.
Full story HERE.
High pressure stimulates growth of new cartilage
HOUSTON, June 4, 2008 -- Bioengineers at Rice University have discovered that intense pressure -- similar to what someone would experience more than a half-mile beneath the ocean's surface -- stimulates cartilage cells to grow new tissue with nearly all of the properties of natural cartilage. The new method, which requires no stem cells, may eventually provide relief for thousands of arthritis sufferers.
"This tissue-engineering method holds promise not only for cartilage but also for tissues to repair bladders, blood vessels, kidneys, heart valves, bones and more," said lead researcher Kyriacos Athanasiou, Rice's Karl F. Hasselmann Professor of Bioengineering.
The findings appear this week in the journal PLoS ONE. They are the latest from the emerging field of tissue engineering, a new discipline that aims to capitalize on the body's innate healing abilities to develop new ways of growing tissues that can be used to surgically repair wounds without risk of rejection.
Full story HERE.
Collision in Saturn's rings
For some time, scientists have suspected the presence of tiny moonlets that orbit Saturn in association with the clumpy ring. As the small satellites move close to the F ring core they leave a gravitational signature. In some cases they can draw out material in the form of a "streamer"--a miniature version of the interaction Cassini has witnessed between Prometheus and the F ring material. The dynamics of this interaction are the same, but the scale is different. See Thieving Moon for a view of Prometheus creating a streamer.
Full story HERE.
Wednesday, June 4, 2008
Microgeneration could rival nuclear power, report shows
British buildings equipped with solar, wind and other micro power equipment could generate as much electricity in a year as five nuclear power stations, a government-backed industry report showed today.
Commissioned by the Department for Business, Energy and Regulatory Reform (DBERR), the report says that if government chose to be as ambitious as some other countries, a combination of loans, grants and incentives could lead to nearly 10m microgeneration systems being installed by 2020.
Such a large scale switch to microrenewable energy could save 30m tonnes of CO2 – the equivalent of nearly 5% of all UK electricity.
The report estimates that there are nearly 100,000 microgeneration units already installed in Britain. Nearly 90,000 of these are solar water heaters, with limited numbers of biomass boilers, photovoltaic panels, heat pumps, fuel cells, and small-scale hydroelectric and windpower schemes.
News flash: Newton's laws were 'overthrown'
Sir Isaac Newton is one of the towering geniuses in all human history. Washington Post columnist Charles Krauthammer? Not so much.
Krauthammer has written a classic anti-science screed, "Carbon Chastity: The First Commandment of the Church of the Environment," that recasts many favorite anti-scientific denier memes in odd terms. You still hear and see all of these today, so let me touch on a few of them. And as I will discuss in Part 2, the article is most useful because it is a very clear statement of the real reason conservatives don't believe in climate science: They hate the solution.
Full editorial HERE.
Tissue of dead humans to be cloned
Health ministers have proposed that laboratories should be allowed to use stored human tissue to create cloned embryonic stem cells without the explicit consent of the tissue donor. This would allow research to be done on tissue donated for medical research as long as 30 years ago. Scientists would also be able to use cells from people who have died since they donated their tissue or who cannot be contacted.
Full story HERE.
Sunday, June 1, 2008
Synthetic Copycat Of Living Cell
Dr Cameron Alexander and PhD student George Pasparakis in the University's School of Pharmacy have used polymers — long-chain molecules — to construct capsule-like structures that have properties mimicking the surfaces of a real cell.
In the new work, they show how in the laboratory they have been able to encourage the capsules to 'talk' to natural bacteria cells and transfer molecular information.
Full story HERE.
Secret messages could be hidden in net phone calls
The next time your internet (VoIP) phone call sounds a bit fuzzy, it might not be your ISP that's to blame. Someone could be trying to squeeze a secret message between the packets of data carrying the caller's voice.
Wojciech Mazurczyk and Krzysztof Szczypiorski, information scientists at the Institute of Telecommunications in Warsaw, Poland, revealed last week that they are developing a "steganographic" system for VoIP networks (www.arxiv.org/abs/0805.2938). Steganography is the art of hiding messages by embedding them in ordinary communications. For example, a message can be encoded as a string of numbers which are used to modify the brightness and colour of an image. The effect is too subtle to be noticed by unwitting observers but the message can be deciphered with appropriate software by anyone who knows it's there.
The full paper is HERE.